Hydrochloric Acid → HCID 20252052, compound

HRID 1284532Notes

Reaction equation

HRID 1284532 reaction equation
[ClH:1].[OH-].[Cl:3][C:4]1[C:21]([S:22](=[O:25])(=[O:24])[NH2:23])=[CH:20][C:7]([C:8]([NH:10][N+:11]2[C:16]([CH3:17])=[CH:15][C:14]([CH3:18])=[CH:13][C:12]=2[CH3:19])=[O:9])=[C:6]([NH:26][CH2:27][C:28]2[O:29][CH:30]=[CH:31][CH:32]=2)[CH:5]=1>C(O)C>[ClH:3].[Cl-:1].[Cl:3][C:4]1[C:21]([S:22](=[O:24])(=[O:25])[NH2:23])=[CH:20][C:7]([C:8]([NH:10][N+:11]2[C:12]([CH3:19])=[CH:13][C:14]([CH3:18])=[CH:15][C:16]=2[CH3:17])=[O:9])=[C:6]([NH:26][CH2:27][C:28]2[O:29][CH:30]=[CH:31][CH:32]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70454011HCID 70454011, compound

Product 1

HCID 20252052HCID 20252052, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

20 ml of ethanol saturated with hydrochloric acid are added, with stirring, to a suspension of the inert salt of 1-{[4-chloro-2-(2-furylmethylamino)-5-sulfamylbenzoyl]-amino}-2,4,6-trimethylpyridinium hydroxide (4.6 g, 0.01 mol) in ethanol (40 ml). After a few seconds, a transparent solution is obtained, which immediately starts to precipitate. The precipitate is filtered off and washed with ethanol, giving 4.9 g (98%) of 1-{[4-chloro-2-(2-furylmethylamino)-5-sulphamylbenzoyl]-amino}-2,4,6-trimethylpyridinium chloride hydrochloride of the formula ##STR15##

Workup

  1. waitAfter a few seconds
  2. customa transparent solution is obtained
  3. customto precipitate
  4. filtrationThe precipitate is filtered off
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-ba032c3e74ad4acebe78428e8445a925
Source dataset
uspto-grants-1986_01
Patent number
US04563467

Reaction notes

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