Imidazole → HCID 497100, compound

HRID 1284548Notes

Reaction equation

HRID 1284548 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.C1(C)C=CC(S(O[CH2:16][C:17]([I:21])=[C:18]([I:20])[I:19])(=O)=O)=CC=1>CN(C=O)C>[I:21][C:17](=[C:18]([I:20])[I:19])[CH2:16][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 132330032,3,3-Triiodoallyl-p-toluenesulfonate

Product 1

HCID 497100HCID 497100, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 340 mg (5 mmoles) of imidazole in 5.0 ml of dry DMF were added 606 mg (1 mmole) of 3-p-toluenesulfonyloxy-1,1,2-triiodo-1-propene and the reaction was effected at 25° C. for 2 hours. The reaction mixture was poured into 20 ml of ice-water while stirring vigorously and the mixture was allowed to stand for a further one hour. The crystalline substance thus separated was recovered by filtration, washed with water and then dried. Yield 440 mg (96%), mp 127°-128° C. (with decomposition).

Workup

  1. waitto stand for a further one hour
  2. customThe crystalline substance thus separated
  3. filtrationwas recovered by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-3abeda2b60df404fb1a0d08c8c524faf
Source dataset
uspto-grants-1986_01
Patent number
US04563472

Reaction notes

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