Nalidixic Acid → Norfloxacin

HRID 1284563Notes

Reaction equation

HRID 1284563 reaction equation
CCN1C2N=C(C)C=CC=2C(=O)C(C(O)=O)=C1.[Na].[CH3:19][CH2:20][N:21]1[C:27]2[CH:28]=[C:29]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)[C:30]([F:32])=[CH:31][C:26]=2[C:24](=[O:25])[C:23]([C:39]([OH:41])=[O:40])=[CH:22]1>>[CH3:19][CH2:20][N:21]1[C:27]2[CH:28]=[C:29]([N:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)[C:30]([F:32])=[CH:31][C:26]=2[C:24](=[O:25])[C:23]([C:39]([OH:41])=[O:40])=[CH:22]1

Participants

3

Reactant 2

HCID 4421Nalidixic AcidHCID 70470528104143-11-5

Product 1

HCID 4539Norfloxacin

Procedure

Samples of these materials were placed in an aqueous solution of a soluble nalidixic acid derivative salt, illustratively a 30 micromole/ml solution of sodium norfloxacin, for a period of about an hour. The samples were removed from the solution and blotted dry. Then, the samples were placed in an aqueous solution of a soluble silver salt such as silver nitrate for a period of time sufficient to allow reaction between the norfloxacin salt and the metal salt so as to produce the metal salt of norfloxacin in, or on, the sample. In the actual tests performed, a period of about five to ten minutes was found to be sufficient.

Workup

  1. customThe samples were removed from the solution
  2. customblotted dry
  3. waitThen, the samples were placed in an aqueous solution of a soluble silver salt such as silver nitrate for a period of time
  4. customreaction between the norfloxacin salt

Sources & evidence

ORD record
ord-20bbfe43ef3740d8b610732709f02e92
Source dataset
uspto-grants-1986_01
Patent number
US04563485

Reaction notes

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