HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(Aminocarbonyl)-2-thiophenecarboxamide → 1-[1-(Naphth-2-ylmethyl)piperid-4-yl]-3-(then-2-oyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(Aminocarbonyl)-2-thiophenecarboxamide | HCID 395032 | — |
| Reactant | 4-Amino-1-(2-naphthyl)methylpiperidine | HCID 11195823 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-[1-(Naphth-2-ylmethyl)piperid-4-yl]-3-(then-2-oyl)urea | HCID 12942334 | — |
Reaction Steps
4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0047 m) and 1-(then-2-oyl)urea (0.65 g, 0.0042 m) in pyridine (5 cm3) was refluxed for 9.5 hours. The solvent was evaporated, water added, and the precipitated title compound filtered and washed well with water. This was recrystallised from ethanol, converted to the hydrochloride salt in ethanol with ethanolic HCl, and recrystallised from ethanol, 0.5 g, at the hydrochloride, m.p. 217°-219° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563466 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-0e3f17421eeb405881d10764a3a81c41 |
| Source note | uspto-grants-1986_01 |