反应详情

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0047 m) and 1-(then-2-oyl)urea (0.65 g, 0.0042 m) in pyridine (5 cm3) was refluxed for 9.5 hours. The solvent was evaporated, water added, and the precipitated title compound filtered and washed well with water. This was recrystallised from ethanol, converted to the hydrochloride salt in ethanol with ethanolic HCl, and recrystallised from ethanol, 0.5 g, at the hydrochloride, m.p. 217°-219° C.

1. customThe solvent was evaporated
2. additionwater added
3. customthe precipitated title compound
4. filtrationfiltered
5. washwashed well with water
6. customThis was recrystallised from ethanol
7. customrecrystallised from ethanol, 0.5 g, at the hydrochloride, m.p. 217°-219° C.