反应详情

A solution of 5.0 g. of 5-(p-aminophenyl)-1-(p-fluorophenyl)-1H-1,2,4-triazole in 20 ml. of dimethylformamide dimethylacetal is heated to reflux for 1.5 hours while the methanol formed is collected by distillation. The reaction mixture is cooled, 15 ml. of ether is added and the mixture is cooled further, giving 5.5 g. of the desired product, mp. 159°-161° C.

1. customformed
2. distillationis collected by distillation
3. temperatureThe reaction mixture is cooled
4. additionof ether is added
5. temperaturethe mixture is cooled further
6. customgiving 5.5 g