Hydrochloric Acid → N-(2-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydrophthalimide

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Reaction Steps

The compound (VI) is prepared by reacting the compound (VIII) with a 1 to 2 equivalent amount of sodium nitrite in a solvent (e.g. sulfuric acid, hydrochloric acid, acetic acid, water) at a temperature of 0° to 20° C. for a period of 5 minutes to 5 hours to obtain its diazonium salt, followed by hydrolysis of the diazonium salt in dilute sulfuric acid at a temperature of 20° to 100° C. In the hydrolysis, a copper compound such as cuprous oxide or cupric nitrate may be used in place of dilute sulfuric acid.

Provenance & Evidence