HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide → N-(2-fluoro-5-aminophenyl)-3,4,5,6-tetrahydrophthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide | HCID 13560456 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(2-fluoro-5-aminophenyl)-3,4,5,6-tetrahydrophthalimide | HCID 10332826 | 99.9% |
Reaction Steps
N-(2-Fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide (VII) (5 g) and platinum dioxide (0.2 g) were suspended in ethyl acetate (50 ml), and the resultant suspension was allowed to catalytic reduction at room temperature under atmospheric pressure until 1.3 liters of hydrogen was taken up. The reaction mixture was filtered and concentrated to give 4.48 g of N-(2-fluoro-5-aminophenyl)-3,4,5,6-tetrahydrophthalimide (VIII). M.P., 117°-119° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04563535 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-0c17a0014699455f8837b7b272c8928a |
| Source note | uspto-grants-1986_01 |