反应详情

N-(2-Fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide (VII) (5 g) and platinum dioxide (0.2 g) were suspended in ethyl acetate (50 ml), and the resultant suspension was allowed to catalytic reduction at room temperature under atmospheric pressure until 1.3 liters of hydrogen was taken up. The reaction mixture was filtered and concentrated to give 4.48 g of N-(2-fluoro-5-aminophenyl)-3,4,5,6-tetrahydrophthalimide (VIII). M.P., 117°-119° C.

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated