反应详情

2-Fluoro-5-nitroaniline (IV) (50 g) and 3,4,5,6-tetrahydrophthalic anhydride (49 g) were dissolved in acetic acid (200 ml), and the resultant solution was heated under reflux for 4 hours. After cooling, the reaction mixture was diluted with water and extracted with ethyl acetate. The extract was concentrated, and the precipitated crystals were collected by filtration to give 72 g of N-(2-fluoro-5-nitrophenyl)-3,4,5,6-tetrahydrophthalimide (VII). M.P., 154.9° C.

1. temperatureunder reflux for 4 hours
2. temperatureAfter cooling
3. extractionextracted with ethyl acetate
4. concentrationThe extract was concentrated
5. filtrationthe precipitated crystals were collected by filtration