HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 23469767, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| Reactant | 4-(Thiophene-2-carbonyl)phenol | HCID 13020505 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | HCID 23469767 | HCID 23469767 | 50% |
Reaction Steps
A mixture of 2-thienyl-(4-hydroxy-phenyl)ketone (M.p. 112° C.; 65 g), ethyl bromoisobutyrate (62 g) and potassium carbonate (88 g) in 2-butanone (500 ml) is refluxed for 24 hours. After removing the solid by filtration in the hot, the solvent is removed. The unreacted phenol is extracted from the residue with an alkaline aqueous solution. The usual treatments give, in a yield of 50%, the ester which melts at 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259509 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-60d9e76de33a42e5a6099966f85d4fb4 |
| Source note | uspto-grants-1981_03 |