Sodium Bicarbonate → Sodium 7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate

HRID 1284727Notes

Reaction equation

HRID 1284727 reaction equation
C(=O)(O)[O-].[Na+:5].Cl.[NH2:7][C:8]1[S:9][CH:10]=[C:11]([C:13](=[N:29][O:30][CH3:31])[C:14]([NH:16][CH:17]2[C:27](=[O:28])[N:19]3[C:20]([C:24]([OH:26])=[O:25])=[CH:21][CH2:22][S:23][C@H:18]23)=[O:15])[N:12]=1>O>[NH2:7][C:8]1[S:9][CH:10]=[C:11]([C:13](=[N:29][O:30][CH3:31])[C:14]([NH:16][CH:17]2[C:27](=[O:28])[N:19]3[C:20]([C:24]([O-:26])=[O:25])=[CH:21][CH2:22][S:23][C@H:18]23)=[O:15])[N:12]=1.[Na+:5]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 1317124437-[2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid hydrochloride

Product 1

HCID 131712445Sodium 7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium bicarbonate (1.04 g.) was added to a solution of 7-{2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylic acid hydrochloride (syn isomer, 2.6 g.) in water (100 ml.) under ice-cooling and stirred at room temperature. The resultant solution was lyophilized to give sodium 7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn isomer).

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-02bc81cf79674ea8ba0ade9eacafe80d
Source dataset
uspto-grants-1986_01
Patent number
US04563522

Reaction notes

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