Thionyl Chloride → HCID 54338259, compound

HRID 1284897Notes

Reaction equation

HRID 1284897 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH:12]=[CH:13][C:14]([C:19]([OH:21])=O)=[CH:15][C:16]=3[C:17]=2[N:18]=1)=[O:5])[CH3:2].S(Cl)([Cl:24])=O>CN(C)C=O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH:12]=[CH:13][C:14]([C:19]([Cl:24])=[O:21])=[CH:15][C:16]=3[C:17]=2[N:18]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 54454612HCID 54454612, compound

Product 1

HCID 54338259HCID 54338259, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

184 mg of 8-hydroxycarbonyl-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester (Example 18) is refluxed for 3 hours in 5 ml of thionyl chloride with one drop of dimethylformamide. After concentration, the mixture is further reacted without any purification.

Workup

  1. concentrationAfter concentration
  2. customthe mixture is further reacted without any purification

Sources & evidence

ORD record
ord-43995509e4274c0e8cbee4bb7dea54b9
Source dataset
uspto-grants-1986_01
Patent number
US04564610

Reaction notes

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