Hydrogen Bromide → HCID 20250687, compound

Participants

Reaction Steps

One gram of 8-amino-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester (Example 11) is combined with such an amount of dimethyl sulfoxide that a clear solution is produced. Then, at 0°-5° C., the same amount of 48% aqueous hydrobromic acid is added dropwise and the mixture stirred thereafter for another 2 hours at this temperature, thus obtaining the ethyl ester of 8-amino-9-bromo-5H-pyrimido[5,4-b]indole-2-carboxylic acid.

Provenance & Evidence