Hydrogen Bromide → HCID 20250687, compound

HRID 1284900Notes

Reaction equation

HRID 1284900 reaction equation
C([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH:12]=[CH:13][C:14]([NH2:19])=[CH:15][C:16]=3[C:17]=2[N:18]=1)=[O:5])C.[BrH:20]>CS(C)=O>[NH2:19][C:14]1[CH:13]=[CH:12][C:11]2[NH:10][C:9]3[CH:8]=[N:7][C:6]([C:4]([OH:3])=[O:5])=[N:18][C:17]=3[C:16]=2[C:15]=1[Br:20]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13321944HCID 13321944, compound

Product 1

HCID 20250687HCID 20250687, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

One gram of 8-amino-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester (Example 11) is combined with such an amount of dimethyl sulfoxide that a clear solution is produced. Then, at 0°-5° C., the same amount of 48% aqueous hydrobromic acid is added dropwise and the mixture stirred thereafter for another 2 hours at this temperature, thus obtaining the ethyl ester of 8-amino-9-bromo-5H-pyrimido[5,4-b]indole-2-carboxylic acid.

Workup

  1. customis produced

Sources & evidence

ORD record
ord-fd43b9f1e59b437bb706af4e9671c0ea
Source dataset
uspto-grants-1986_01
Patent number
US04564610

Reaction notes

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