Isoamyl Nitrite → HCID 54272265, compound

HRID 1284901Notes

Reaction equation

HRID 1284901 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH:12]=[CH:13][C:14](N)=[C:15]([Br:19])[C:16]=3[C:17]=2[N:18]=1)=[O:5])[CH3:2].N(OCCC(C)C)=O>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[CH:12]=[CH:13][CH:14]=[C:15]([Br:19])[C:16]=3[C:17]=2[N:18]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 8053Isoamyl NitriteHCID 53838271HCID 53838271, compound

Product 1

HCID 54272265HCID 54272265, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 1 g of 8-amino-9-bromo-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester in 70 ml of ethanol is combined with 1.8 ml of isoamyl nitrite. The mixture is refluxed for one hour and then concentrated. Yield: 0.2 g of 9-bromo-5H-pyrimido[5,4-b]indole-2-carboxylic acid ethyl ester.

Workup

  1. temperatureThe mixture is refluxed for one hour
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-0235332ad24342a6b2dd71443305eff5
Source dataset
uspto-grants-1986_01
Patent number
US04564610

Reaction notes

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