反应详情

To a mixture of 10.01 g. of 4-(benzyloxy)phenol and 3.51 g. (0.05 mole) of potassium methoxide in 75 ml. of DMF is added 12.08 g. (0.05 mole) of 4-(trifluoromethoxy)-2-nitro-1-chlorobenzene. The mixture is heated to complete the reaction. Most of the solvent is removed at reduced pressure and the residue treated with methylene chloride and water. The methylene chloride solution is washed with saturated brine, dried, and the solvent removed, leaving 4-[4-(trifluoromethoxy)-2-nitrophenoxy]-phenyl benzyl ether.

1. additionTo a mixture of 10.01 g
2. temperatureThe mixture is heated
3. customthe reaction
4. customMost of the solvent is removed at reduced pressure
5. additionthe residue treated with methylene chloride and water
6. washThe methylene chloride solution is washed with saturated brine
7. customdried
8. customthe solvent removed