Sodium Hydroxide → HCID 23666319, compound

HRID 1284942Notes

Reaction equation

HRID 1284942 reaction equation
[OH-].[Na+:2].C([O:5][C:6]([C@@H:8]([NH:17][C@@H:18]1[C:24](=[O:25])[N:23]([CH2:26][C:27]([OH:29])=[O:28])[C:22]2[CH:30]=[CH:31][CH:32]=[CH:33][C:21]=2[S:20][CH2:19]1)[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])C>C(O)C>[Na+:2].[C:6]([C@@H:8]([NH:17][C@@H:18]1[C:24](=[O:25])[N:23]([CH2:26][C:27]([O-:29])=[O:28])[C:22]2[CH:30]=[CH:31][CH:32]=[CH:33][C:21]=2[S:20][CH2:19]1)[CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13375116HCID 13375116, compound

Product 1

HCID 23666319HCID 23666319, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2 ml of ethanol, 6 ml of 1N aqueous sodium hydroxide and 0.2 g of 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid obtained in Example 7 is allowed to stand at room temperature for 30 minutes and concentrated under reduced pressure at room temperature to about 1 ml. The concentrated solution is acidified slightly with acetic acid, and the deposited colorless prisms are collected by filtration to yield 0.134 g of 3(R)-[1(S)-carboxy-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid monosodium salt, m.p. 166°-169° C.

Workup

  1. concentrationconcentrated under reduced pressure at room temperature to about 1 ml
  2. filtrationthe deposited colorless prisms are collected by filtration

Sources & evidence

ORD record
ord-eeebcffefbd243c59c3e0e70059a4b3a
Source dataset
uspto-grants-1986_01
Patent number
US04564612

Reaction notes

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