Sodium Hydroxide → HCID 23666319, compound

Participants

Reaction Steps

A mixture of 2 ml of ethanol, 6 ml of 1N aqueous sodium hydroxide and 0.2 g of 3(R)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid obtained in Example 7 is allowed to stand at room temperature for 30 minutes and concentrated under reduced pressure at room temperature to about 1 ml. The concentrated solution is acidified slightly with acetic acid, and the deposited colorless prisms are collected by filtration to yield 0.134 g of 3(R)-[1(S)-carboxy-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid monosodium salt, m.p. 166°-169° C.

Provenance & Evidence