Hydrochloric Acid → HCID 70456429, compound

HRID 1284945Notes

Reaction equation

[CH2:1]([O:8][C:9]([C@@H:11]([NH:20][C@@H:21]1[C:27](=[O:28])[N:26]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:25]2[CH:37]=[CH:38][CH:39]=[CH:40][C:24]=2[S:23][CH2:22]1)[CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:41]>>[ClH:41].[CH2:1]([O:8][C:9]([C@@H:11]([NH:20][C@@H:21]1[C:27](=[O:28])[N:26]([CH2:29][C:30]([OH:32])=[O:31])[C:25]2[CH:37]=[CH:38][CH:39]=[CH:40][C:24]=2[S:23][CH2:22]1)[CH2:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 54341310HCID 54341310, compound

Product 1

HCID 70456429HCID 70456429, compound

Procedure

In a manner similar to that described in Example 5, 0.35 g of tert-butyl 3(R)-[1(S)-benzyloxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate obtained in Example 44 is treated with hydrogen chloride to give 0.25 g of 3(R)-[1(S)-benzyloxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid hydrochloride as colorless powder.

Sources & evidence

ORD record: ord-ee5a781ae7044a41b087f3e1c6b6cf7d
Source dataset: uspto-grants-1986_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04564612

Reaction notes

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