HCID 13605313, compound → HCID 13605326, compound

HRID 1284953Notes

Reaction equation

HRID 1284953 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C@H:18]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[S:27][CH2:26]1)[C:19]([O:21][CH2:22][CH3:23])=[O:20])=O)(C)(C)C.C(OCC)(=O)C.[ClH:51]>CCOCC>[ClH:51].[ClH:51].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C@H:18]([NH:24][C@@H:25]1[C:31](=[O:32])[N:30]([CH2:33][C:34]([OH:36])=[O:35])[C:29]2[CH:41]=[CH:42][CH:43]=[CH:44][C:28]=2[S:27][CH2:26]1)[C:19]([O:21][CH2:22][CH3:23])=[O:20]

Participants

4

Reactant 2

HCID 13605313HCID 13605313, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13605326HCID 13605326, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of tert-butyl 3(R)-[10-tert-butoxycarbonylamino-1(S)-ethoxycarbonyldecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate (0.3 g) in a hydrogen chloride-ethyl acetate solution (5N, 10 ml) stands for 3 hours at room temperature, and then a mixture of ether and petroleum ether is added. After agitating thoroughly, the supernatant is removed by decantation. The deposited precipitate is dried under reduced pressure to provide 3(R)-[10-amino-1(S)-ethoxycarbonyldecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrochloride (0.23) g as a colorless powder.

Workup

  1. additionis added
  2. customthe supernatant is removed by decantation
  3. customThe deposited precipitate is dried under reduced pressure

Sources & evidence

ORD record
ord-b94ac9c3a81a4c519ad78f7ef2a45503
Source dataset
uspto-grants-1986_01
Patent number
US04564612

Reaction notes

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