HCID 13605313, compound → HCID 13605326, compound

Participants

Reaction Steps

A solution of tert-butyl 3(R)-[10-tert-butoxycarbonylamino-1(S)-ethoxycarbonyldecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate (0.3 g) in a hydrogen chloride-ethyl acetate solution (5N, 10 ml) stands for 3 hours at room temperature, and then a mixture of ether and petroleum ether is added. After agitating thoroughly, the supernatant is removed by decantation. The deposited precipitate is dried under reduced pressure to provide 3(R)-[10-amino-1(S)-ethoxycarbonyldecyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrochloride (0.23) g as a colorless powder.

Provenance & Evidence