Methanesulfonic Acid → 2,3-Dihydro-2-methyl-1H-indol-1-amine monomethanesulphonate

Participants

Reaction Conditions

Reaction Steps

10 g of crude 1-amino-2-methylindoline (made as described in Example 1) was dissolved in 40 ml of isopropanol. 6.75 g of methanesulfonic acid was added and the solution was cooled to about 0° C. to obtain crystals of 1-amino-2-methylindoline methanesulfonate which was isolated by filtration. The crystals were then washed by slurrying with fresh isopropanol and dried at 20° C. Melting range of product compound was 170°-2° C.

Provenance & Evidence