Methanesulfonic Acid → 2,3-Dihydro-2-methyl-1H-indol-1-amine monomethanesulphonate
Reaction equation
[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11].[CH3:12][S:13]([OH:16])(=[O:15])=[O:14]>C(O)(C)C>[CH3:12][S:13]([OH:16])(=[O:15])=[O:14].[NH2:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH:3]1[CH3:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
10 g of crude 1-amino-2-methylindoline (made as described in Example 1) was dissolved in 40 ml of isopropanol. 6.75 g of methanesulfonic acid was added and the solution was cooled to about 0° C. to obtain crystals of 1-amino-2-methylindoline methanesulfonate which was isolated by filtration. The crystals were then washed by slurrying with fresh isopropanol and dried at 20° C. Melting range of product compound was 170°-2° C.
Sources & evidence
- ORD record
- ord-99cf2248145947fa9491aaba94b819f8
- Source dataset
- uspto-grants-1986_01
- Patent number
- US04564677
Reaction notes
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