HCID 20251299, compound → HCID 178463644, compound

HRID 1284976Notes

Reaction equation

HRID 1284976 reaction equation
[C:1]([NH:4][C:5]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:6]=1)(=O)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:1]([NH:4][C:5]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:18])([F:19])[F:17])[CH:11]=2)[N:6]=1)[CH3:2]

Participants

4

Reactant 2

HCID 20251299HCID 20251299, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 178463644HCID 178463644, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By a method analogous to that described in Example 1 3-acetamido-1-(3-trifluoromethylphenyl)-2-pyrazoline was reduced with lithium aluminium hydride, using tetrahydrofuran in place of diethyl ether. The hydrochloride of the resulting 3-ethylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline was recrystallized from isopropanol and diethylether, m.p. 171.5°.

Workup

  1. customThe hydrochloride of the resulting 3-ethylamino-1-(3-trifluoromethylphenyl)-2-pyrazoline was recrystallized from isopropanol and diethylether, m.p. 171.5°

Sources & evidence

ORD record
ord-6232097438a14cffbc92a3f74a1844f8
Source dataset
uspto-grants-1986_01
Patent number
US04564684

Reaction notes

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