反应详情

After ice-cooling 20 ml of an acetic acid solution of 25% hydrobromic acid, 1.91 g of compound (6) was added to the solution followed by reaction for 2 hours at 5°-10° C. The reaction mixture was added to 200 ml of dry ether and after quickly removing the precipitates thus formed by filtration and then the reaction mixture was dried overnight in a desiccator with potassium hydroxide, to provide 1.99 g of L-histidyl-L-proline benzyl ester.2-hydrobromide (7).

1. additionwas added to the solution
2. customfollowed by reaction for 2 hours at 5°-10° C
3. customafter quickly removing the
4. customprecipitates thus
5. customformed by filtration
6. dry with materialthe reaction mixture was dried overnight in a desiccator with potassium hydroxide