Hydrochloric Acid → HCID 20186269, compound

HRID 1285025Notes

Reaction equation

HRID 1285025 reaction equation
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][O:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:16](Cl)(=[O:18])[CH3:17].Cl>C(Cl)Cl>[CH3:5][O:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16](=[O:18])[CH3:17])=[CH:12][CH:11]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 6367Acetyl chlorideHCID 5764101-METHOXY-3-PHENYLPROPANEHCID 6451240Aluminum(III) Chloride

Product 1

HCID 20186269HCID 20186269, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Next, 195 g of AlCl3 and 100 g of 3-methoxypropylbenzene were poured into 1.5 liters of CH2Cl2, and the resulting mixture was cooled with ice under stirring. Thereto was gradually added dropwise 79 g of acetyl chloride (CH3COCl), and the thus obtained mixture was stirred under ice-cooling continuously for 6 hours. After the termination of the evolution of hydrogen chloride (HCl) gas was ascertained, the reaction solution was poured into 1 liter of dilute hydrochloric acid, and the CH2Cl2 layer was separated, after which the CH2Cl2 was distilled off, and the residue was distilled under reduced pressure to obtain p-(3-methoxypropyl)acetophenone. The boiling point of this compound was 94-95° C./0.3 mmHg.

Workup

  1. temperaturethe resulting mixture was cooled with ice
  2. stirringthe thus obtained mixture was stirred under ice-
  3. temperaturecooling continuously for 6 hours
  4. customthe CH2Cl2 layer was separated
  5. distillationafter which the CH2Cl2 was distilled off
  6. distillationthe residue was distilled under reduced pressure

Sources & evidence

ORD record
ord-fd95c220d1a44acc9ca2881b7f8ab60c
Source dataset
uspto-grants-1986_01
Patent number
US04564694

Reaction notes

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