反应详情

Heating a mixture of 1-tert-butyl-5-chloro-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (100 mg; 0.30 mmol) and pyrrolidine (0.25 mL; 3.0 mmol) under microwave irradiation according to the procedure described in Example 37, Step 5 provided after purification by reverse phase HPLC, 1-tert-butyl-5-piperidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (14 mg, 16%) as an white solid. ES-HRMS m/e calcd for C22H34N4O (M+H+) 371.2806, found 371.2801.

1. temperatureHeating
2. customunder microwave irradiation
3. customprovided
4. customafter purification by reverse phase HPLC, 1-tert-butyl-5-piperidin-1-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (14 mg, 16%) as an white solid