N-benzyloxy carbonyl-N-methyl-2-aminoethanol phosphocholine → 2-Methylaminoethanol phosphocholine

HRID 1285106Notes

Reaction equation

HRID 1285106 reaction equation
[P:1]([O:5][CH2:6][CH2:7][N+:8]([CH3:11])([CH3:10])[CH3:9])([OH:4])([OH:3])=[O:2].C(O[N:20]([CH3:26])[CH2:21][C:22](=C=O)[OH:23])C1C=CC=CC=1.[H][H]>O1CCOCC1.O.[Pd]>[P:1]([O:5][CH2:6][CH2:7][N+:8]([CH3:11])([CH3:10])[CH3:9])([OH:3])([OH:4])=[O:2].[CH3:26][NH:20][CH2:21][CH2:22][OH:23]

Participants

6

Reactant 2

HCID 86740600N-benzyloxy carbonyl-N-methyl-2-aminoethanol phosphocholineHCID 178418361HCID 178418361, compound

Product 1

HCID 867405992-Methylaminoethanol phosphocholine

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

8 g of N-benzyloxy carbonyl-N-methyl-2-aminoethanol phosphocholine are dissolved in 60 ml of dioxane and 15 ml of water; the solution is mixed with 0.8 g of 10% palladium active carbon and the reaction mixture hydrogenated with hydrogen. After the H2 -absorption has terminated, the solution is filtered and the filtrate reduced in vacuo to dryness.

Workup

  1. customAfter the H2 -absorption has terminated
  2. filtrationthe solution is filtered

Sources & evidence

ORD record
ord-a4844590bb254ef59569066638e47fec
Source dataset
uspto-grants-1986_01
Patent number
US04565659

Reaction notes

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