反应详情

A mixture of 135 mg of free histamine and 180 mg of 2-methylthio-4-oxo-3H-pyrazolo(1,5-a)-1,3,5-triazine in 10 ml of xylene is refluxed for 22 hrs. After evaporation of the solvent in vacuo, the pale pink residue is triturated with water and alcohol, filtered, washed with ether and dried to yield 120 mg of purified product. TLC (silica gel CHCl3 /MeOH/triethylamine=3:1:0-5) Rf=0.14.

1. temperatureis refluxed for 22 hrs
2. customAfter evaporation of the solvent in vacuo
3. customthe pale pink residue is triturated with water and alcohol
4. filtrationfiltered
5. washwashed with ether
6. customdried