p-Toluenesulfonic acid monohydrate → HCID 20249885, compound

HRID 1285127Notes

Reaction equation

HRID 1285127 reaction equation
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.O.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([OH:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1>CO>[C:16]1([CH3:26])[CH:17]=[CH:18][C:19]([S:22]([OH:25])(=[O:23])=[O:24])=[CH:20][CH:21]=1.[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

Product 1

HCID 20249885HCID 20249885, compoundYield 62.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.88 g) in methanol (30 ml), p-toluenesulfonic acid monohydrate (0.97 g) was gradually added. The reaction mixture was stirred at room temperature for 30 minutes. Methanol was removed under reduced pressure and the residue was recrystallized from ethanol to give 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate (1 g, yield 62.5%) as yellow fine needles.

Workup

  1. customMethanol was removed under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-ac70f367dd39476eb09431d1f6e3527f
Source dataset
uspto-grants-1986_01
Patent number
US04565813

Reaction notes

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