Trifluoroacetic acid → HCID 70433992, compound

HRID 1285139Notes

Reaction equation

C(OC([NH:8][CH2:9][CH:10]([CH3:26])[C:11]([N:13]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1)=[O:12])=O)(C)(C)C.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:8][CH2:9][CH:10]([CH3:26])[C:11]([N:13]1[C@H:22]([C:23]([OH:25])=[O:24])[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1)=[O:12]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 18596601HCID 18596601, compound

Product 1

HCID 70433992HCID 70433992, compound

Procedure

The (3S)-2-[(2RS)-3-tert.butoxycarbonylamino-2-methylpropanoyl]-3-carboxy-1,2,3,4-tetrahydroisoquinoline obtained is treated with trifluoroacetic acid according to the method in Example 1 (Step E), providing (3S)-2-[(2RS)-3-amino-2-methylpropanoyl]-3-carboxy-1,2,3,4-tetrahydroisoquinoline trifluoroacetate, which is transformed into the hydrochloride by being dissolved in an excess of normal HCl and concentrated to dryness.

Sources & evidence

ORD record: ord-4135f19404e345e6be2a526618c942f2
Source dataset: uspto-grants-1986_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04565819

Reaction notes

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