2-(Theophyllin-7-yl)-acetamidoxime → 1H-Purine-2,6-dione, 3,7-dihydro-7-((5-(2-(diethylamino)ethyl)-1,2,4-oxadiazol-3-yl)methyl)-1,3-dimethyl-

Participants

Reaction Steps

5.04 g. of 2-(theophyllin-7-yl)-acetamidoxime, 2.16 g. of sodium methylate, 6.4 g. of diethylamino propionic acid ethyl ester and 100 cm3 of toluene are reacted according to Example a. 6.3 g. (87% yield) of 7-[{5-(2-diethylamino-ethan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline are obtained. M.p.: 69°-70° C. (cyclohexane).

Provenance & Evidence