Isopropylamine → HCID 20249977, compound

HRID 1285170Notes

Reaction equation

HRID 1285170 reaction equation
[CH2:1]([C:6]1[O:10][N:9]=[C:8]([CH2:11][N:12]2[C:21]3[C:20](=[O:22])[N:18]([CH3:19])[C:17](=[O:23])[N:16]([CH3:24])[C:15]=3[N:14]=[CH:13]2)[N:7]=1)[CH2:2][C:3](=O)[CH3:4].[CH:25]([NH2:28])([CH3:27])[CH3:26]>C1C=CC=CC=1>[CH:25]([NH:28][CH:3]([CH3:4])[CH2:2][CH2:1][C:6]1[O:10][N:9]=[C:8]([CH2:11][N:12]2[C:21]3[C:20](=[O:22])[N:18]([CH3:19])[C:17](=[O:23])[N:16]([CH3:24])[C:15]=3[N:14]=[CH:13]2)[N:7]=1)([CH3:27])[CH3:26]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 20249946HCID 20249946, compound

Product 1

HCID 20249977HCID 20249977, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3.32 g. of 7-[{5-(butan-3-on-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline prepared according to the previous Example are heated in 80 cm3 benzene with 6 cm3 isopropylamine under pressure at 80° C. for 4 hours. The mixture is evaporated and the residue is dissolved in 80 cm3 methanol and reduced with 0.8 g. of sodium tetrahydroborate. 2.0 g. (53% yield) of 7-[{5-(3-isopropylamino-butan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline are obtained. M.p.: 55°-61° C.

Workup

  1. customThe mixture is evaporated
  2. dissolutionthe residue is dissolved in 80 cm3 methanol

Sources & evidence

ORD record
ord-6759af5cb9cb444fb988c27f134779a7
Source dataset
uspto-grants-1986_01
Patent number
US04565817

Reaction notes

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