Isopropylamine → HCID 20249977, compound

Participants

Reaction Steps

3.32 g. of 7-[{5-(butan-3-on-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline prepared according to the previous Example are heated in 80 cm3 benzene with 6 cm3 isopropylamine under pressure at 80° C. for 4 hours. The mixture is evaporated and the residue is dissolved in 80 cm3 methanol and reduced with 0.8 g. of sodium tetrahydroborate. 2.0 g. (53% yield) of 7-[{5-(3-isopropylamino-butan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline are obtained. M.p.: 55°-61° C.

Provenance & Evidence