化工社化工社 化学情報印刷レポート · 研究参考用
Butyric acid, 4-diethylamino-, ethyl ester → 7-[{5-(3-Diethylamino-propan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline maleinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Butyric acid, 4-diethylamino-, ethyl ester | HCID 45407 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | 2-(Theophyllin-7-yl)-acetamidoxime | HCID 3057490 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 7-[{5-(3-Diethylamino-propan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline maleinate | HCID 70414187 | 77% |
反応手順
25.2 g. of 2-(theophyllin-7-yl)-acetamidoxime, 200 cm3 toluene and 6.8 g. of sodium ethylate and 37.4 g. of γ-diethylamino-butyric acid ethyl ester are reacted according to Example 4a and thus 38 g. (77% yield) of 7-[{5-(3-diethylamino-propan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline maleinate are obtained. Melting point: 119°-121° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04565817 |
| 出典データセット | uspto-grants-1986_01 |
| ORD ID | ord-da41e0d475a34a0290fb6d2d6b2eb76e |
| 出典メモ | uspto-grants-1986_01 |