反应详情

25.2 g. of 2-(theophyllin-7-yl)-acetamidoxime, 200 cm3 toluene and 6.8 g. of sodium ethylate and 37.4 g. of γ-diethylamino-butyric acid ethyl ester are reacted according to Example 4a and thus 38 g. (77% yield) of 7-[{5-(3-diethylamino-propan-1-yl)-1,2,4-oxadiazol-3-yl}-methyl]-theophylline maleinate are obtained. Melting point: 119°-121° C.