HuagongsheHuagongshe Chemistry Print Report · For research reference only
Theophylline → 7-[2-(5-Methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Theophylline | HCID 2153 | — |
| Reactant | 3-Ethenyl-5-methyl-1,2,4-oxadiazole | HCID 12551458 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-[2-(5-Methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline | HCID 20249918 | 72% |
Reaction Steps
2.2 g. of 3-vinyl-5-methyl-1,2,4-oxadiazole, 30 cm3 dimethylformamide and 0.2 cm3Triton-B catalyst are boiled with 3.6 g. of theophylline for 1 hour. The solvent is distilled off and the residue is crystallized from ethanol. 4.2 g. (72% yield) of 7-[2-(5-methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline are obtained. m.p.: 112°-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04565817 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-5270524b2ee242a68e0e92835a4cd586 |
| Source note | uspto-grants-1986_01 |