反应详情

2.2 g. of 3-vinyl-5-methyl-1,2,4-oxadiazole, 30 cm3 dimethylformamide and 0.2 cm3Triton-B catalyst are boiled with 3.6 g. of theophylline for 1 hour. The solvent is distilled off and the residue is crystallized from ethanol. 4.2 g. (72% yield) of 7-[2-(5-methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline are obtained. m.p.: 112°-114° C.

1. distillationThe solvent is distilled off
2. customthe residue is crystallized from ethanol