HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 7-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione | HCID 76011 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo- | HCID 610234 | 88% |
Reaction Steps
57.9 g. of 7-(3-chloro-propan-1-yl)-theophylline, 12.29 g. of sodium cyanide, 2.0 g. of sodium iodide and 400 cm3 of dimethylformamide are stirred at 90° C. for 3 hours. 49.1 g. (88% yield) of γ-(theophylline-7-yl)-butyronitrile are obtained. M.p.: 146°-150° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04565817 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-5775af0a11f74eaeac2e66a0d237763a |
| Source note | uspto-grants-1986_01 |