p-Toluenesulfonic acid → HCID 54309766, compound

HRID 128520Notes

Reaction equation

HRID 128520 reaction equation
[Br:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[C:18]([F:23])=[C:17]([F:24])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[Br:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[C:18]([F:23])=[C:17]([F:24])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 21753181HCID 21753181, compound

Product 1

HCID 54309766HCID 54309766, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60 g of crude diethyl (2-bromo-3,4,5,6-tetrafluorobenzoyl)-malonate are introduced into 150 ml of water, 0.6 g of 4-toluenesulphonic acid is added and the mixture is heated under reflux for 6 hours. It is extracted with methylene chloride and the extract is washed with water, dried with Na2SO4 and concentrated.

Workup

  1. additionis added
  2. temperaturethe mixture is heated
  3. temperatureunder reflux for 6 hours
  4. extractionIt is extracted with methylene chloride
  5. washthe extract is washed with water
  6. dry with materialdried with Na2SO4
  7. concentrationconcentrated

Sources & evidence

ORD record
ord-b5c3ceb308fa40efbab55cfca3783eee
Source dataset
uspto-grants-1995_11
Patent number
US05464796

Reaction notes

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