Acetic Anhydride → HCID 53682753, compound

HRID 128521Notes

Reaction equation

HRID 128521 reaction equation
[Br:1][C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[C:20]([O:23][C:24](=O)C)(=O)[CH3:21].C(OCC)(OCC)OCC>>[Br:1][C:2]1[C:15]([F:16])=[C:14]([F:17])[C:13]([F:18])=[C:12]([F:19])[C:3]=1[C:4]([C:6](=[CH:24][O:23][CH2:20][CH3:21])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 31214Ethyl orthoformateHCID 54309766HCID 54309766, compound

Product 1

HCID 53682753HCID 53682753, compound

Procedure

45 g of crude ethyl (2-bromo-3,4,5,6-tetrafluorobenzoyl)-acetate are introduced into 32.2 g (0.31 mol) of acetic anhydride and 28.4 g (0.19 mol) of triethyl orthoformate and the mixture is heated under reflux for 2 hours. Excess reagent is stripped off, first in vacuo and then under a high vacuum (bath up to 120°-130° C.), and the crude product is reacted for the next stage.

Workup

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 2 hours

Sources & evidence

ORD record
ord-f431c23b59b84da3bb5ec0ea772355de
Source dataset
uspto-grants-1995_11
Patent number
US05464796

Reaction notes

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