Acetic Anhydride → HCID 53682753, compound

Participants

Reaction Steps

45 g of crude ethyl (2-bromo-3,4,5,6-tetrafluorobenzoyl)-acetate are introduced into 32.2 g (0.31 mol) of acetic anhydride and 28.4 g (0.19 mol) of triethyl orthoformate and the mixture is heated under reflux for 2 hours. Excess reagent is stripped off, first in vacuo and then under a high vacuum (bath up to 120°-130° C.), and the crude product is reacted for the next stage.

Provenance & Evidence