Benzene → HCID 13576785, compound

HRID 1285228Notes

Reaction equation

HRID 1285228 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][C@@H:15]([CH3:19])[C:16](O)=[O:17])(=[O:13])=[O:12].C1C=CC=CC=1.S(Cl)([Cl:28])=O>CCCCCC>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][C@@H:15]([CH3:19])[C:16]([Cl:28])=[O:17])(=[O:13])=[O:12]

Participants

5

Reactant 3

HCID 241Benzene2×HCID 24386Thionyl ChlorideHCID 776669HCID 776669, compound

Product 1

HCID 13576785HCID 13576785, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

2 g of (S)-2-(2-naphthylsulfonylamino)propionic acid are added to 50 ml of anhydrous benzene, and 2.04 ml of thionyl chloride are added thereto. The mixture is stirred at 40° to 50° C for 18 hours. The reaction mixture is condensed to dryness under reduced pressure, and the residue is recystallized from a mixture of benzene and n-hexane. 1.6 g of (S)-2-(2-naphthylsulfonylamino)propionyl chloride are obtained.

Workup

  1. additionare added
  2. customcondensed to dryness under reduced pressure

Sources & evidence

ORD record
ord-7b0d3a249bdc45bfb240628f82ef8a34
Source dataset
uspto-grants-1986_01
Patent number
US04565877

Reaction notes

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