HCID 20250470, compound → HCID 20250467, compound

HRID 1285261Notes

Reaction equation

HRID 1285261 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[C:6]([CH2:21][CH2:22][CH3:23])[C:7]([O:13]CC3C=CC=CC=3)=[CH:8][CH:9]=2)[O:4]1>CO.[Pd]>[OH:1][CH2:2][CH:3]1[CH2:12][CH2:11][C:10]2[C:5](=[C:6]([CH2:21][CH2:22][CH3:23])[C:7]([OH:13])=[CH:8][CH:9]=2)[O:4]1

Participants

4

Reactant 1

HCID 20250470HCID 20250470, compound

Product 1

HCID 20250467HCID 20250467, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

3.97 g (12.7 mmole) of the compound from Example 33 was dissolved in 30 ml of methanol and 397 mg of 5% palladium on carbon was added. The resulting suspension was hydrogenated at 60 psi and 60° C. for 46 minutes. After cooling and removal of the catalyst by filtration, the solvent was removed by rotary evaporation to give 2.80 g (99%) of the title compound as a light yellow oil. Calc: C, 70.25; H, 8.16; Found: C, 69.54; H 8.18.

Workup

  1. temperatureAfter cooling
  2. customremoval of the catalyst
  3. filtrationby filtration
  4. customthe solvent was removed by rotary evaporation

Sources & evidence

ORD record
ord-3ccb8b07c6f940138375cfe5f490a1f8
Source dataset
uspto-grants-1986_01
Patent number
US04565882

Reaction notes

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