Water → HCID 19374415, compound

HRID 128527Notes

Reaction equation

HRID 128527 reaction equation
[Cl:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[C:18]([Cl:23])=[C:17](F)[C:3]=1[C:4]([C:6](=[CH:12][NH:13][CH:14]1[CH2:16][CH2:15]1)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[F-].[Na+].O>CN1CCCC1=O>[Cl:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[C:18]([Cl:23])=[C:17]2[C:3]=1[C:4](=[O:5])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:12][N:13]2[CH:14]1[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 962WaterHCID 5235Sodium FluorideHCID 178471889HCID 178471889, compound

Product 1

HCID 19374415HCID 19374415, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

19.1 g (0.05 mol) of ethyl 2-(2,5-dichloro-3,4,6-trifluorobenzoyl)-3-cyclopropylamino-acrylate are heated at 160°-170° C. together with 4.2 g (0.1 mol) of sodium fluoride in 100 ml of N-methyl-2-pyrrolidone for 5 hours. After cooling, the mixture is poured onto 200 ml of water. The solid which has precipitated is filtered off with suction, washed with water and dried at 80° C. in a drying cabinet.

Workup

  1. temperatureAfter cooling
  2. customThe solid which has precipitated
  3. filtrationis filtered off with suction
  4. washwashed with water
  5. customdried at 80° C. in a drying cabinet

Sources & evidence

ORD record
ord-b0458caa17c54160831f9003ab4d7acb
Source dataset
uspto-grants-1995_11
Patent number
US05464796

Reaction notes

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