Hydrochloric Acid → 4-Chlorotoluene-2-sulphonyl chloride

Temperature

15 °C

5-Chloro-2-methylbenzeneamine (1002 g) was added over 0.5 hr. to a stirred mixture of 5.5 L of concentrated hydrochloric acid and 1.5 L of acetic acid precooled to 0°-5° C. The resulting suspension was stirred 0.5 hr. A solution of 530 g of sodium nitrite in 0.9 L H2O was added over 1.0 hr. while maintaining the temperature at 0°-5° C. When addition was complete, the mixture was stirred 1.0 hr. at 0°-5° C. The diazonium salt was added to a stirred mixture of 6.0 L of acetic acid, 1000 g of sulfur dioxide and 16.8 g of cuprous chloride while maintaining the temperature about 15° C. When addition of the diazonium salt was complete, the mixture was stirred several hours at about 15° C. then allowed to warm to ambient temperature and stirred overnight. The reaction mixture was poured into ice-water, and the aqueous mixture was extracted with 12 L of methylene chloride. The organic solution was washed twice with 6 L water followed twice with 4 L of saturated sodium bicarbonate solution. The organic solution was dried over magnesium sulfate, filtered and the solvent evaporated in vacuo to give 1279.9 g of the title compound as a black oil.

1. customprecooled to 0°-5° C
2. temperaturewhile maintaining the temperature at 0°-5° C
3. additionWhen addition
4. stirringthe mixture was stirred 1.0 hr
5. customat 0°-5° C
6. stirringthe mixture was stirred several hours at about 15° C.
7. temperatureto warm to ambient temperature
8. stirringstirred overnight
9. extractionthe aqueous mixture was extracted with 12 L of methylene chloride
10. washThe organic solution was washed twice with 6 L water
11. dry with materialThe organic solution was dried over magnesium sulfate
12. filtrationfiltered
13. customthe solvent evaporated in vacuo

ORD record

ord-5bc7bace478b432f9321c07ccb82cf1a

Source dataset

uspto-grants-1986_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04566898