Methylamine → HCID 20248698, compound

HRID 1285281Notes

Reaction equation

HRID 1285281 reaction equation
[C:1]1([C:7](=[O:20])[CH:8]([CH3:19])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N:16]=[C:17]=[O:18])=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][NH2:22]>C1(C)C=CC=CC=1>[C:1]1([C:7](=[O:20])[CH:8]([CH3:19])[CH2:9][C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]([NH:22][CH3:21])=[O:18])=[CH:14][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20248703HCID 20248703, compound

Product 1

HCID 20248698HCID 20248698, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent3×

Conditions

Temperature
40 °C

Procedure

A solution of 13.25 g of 4-(3-phenyl-2-methyl-n-propan-3-onyl)-phenyl isocyanate in 20 ml of toluene was added dropwise to a solution of 3 g of methylamine in 100 ml of toluene, at from 20° to 25° C. The mixture was stirred for 6 hours at 40° C., after which the toluene was stripped off under reduced pressure. 13.3 g (90% of theory) of a slightly yellow oil were obtained.

Workup

  1. custom13.3 g (90% of theory) of a slightly yellow oil were obtained

Sources & evidence

ORD record
ord-c0fe12d36bfb4abf864ef1de1c402ab7
Source dataset
uspto-grants-1986_01
Patent number
US04566900

Reaction notes

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