HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 178506810, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Phosphonic acid, (difluoromethyl)-, diethyl ester | HCID 2758305 | — |
| Reactant | Acetone cardice | HCID 18522661 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178506810 | HCID 178506810 | — |
Reaction Steps
A 5° solution of lithium diisopropylamide in THF (7.7 mmol, 17 ml) is added slowly (10 min) to a solution of diethyl difluoromethylphosphonate (8 mmol, 1.5 g) in THF (20 ml) with dry ice/acetone cooling. The mixture is stirred for 5 min before steroid addition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04567000 |
| Source dataset | uspto-grants-1986_01 |
| ORD ID | ord-81ffc4330cd74284baa2b787081103d0 |
| Source note | uspto-grants-1986_01 |