Lithium diisopropylamide → HCID 178506810, compound

HRID 1285290Notes

Reaction equation

HRID 1285290 reaction equation
C([N-][CH:5]([CH3:7])C)(C)C.[Li+:8].[F:9][CH:10]([P:12](=[O:19])(OCC)OCC)[F:11].C(=O)=O.C[C:24]([CH3:26])=O>C1COCC1>[CH2:24]([P:12]([C:10]([Li:8])([F:9])[F:11])([CH2:5][CH3:7])=[O:19])[CH3:26]

Participants

5

Reactant 3

HCID 2724682Lithium diisopropylamideHCID 2758305Phosphonic acid, (difluoromethyl)-, diethyl esterHCID 18522661Acetone cardice

Product 1

HCID 178506810HCID 178506810, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A 5° solution of lithium diisopropylamide in THF (7.7 mmol, 17 ml) is added slowly (10 min) to a solution of diethyl difluoromethylphosphonate (8 mmol, 1.5 g) in THF (20 ml) with dry ice/acetone cooling. The mixture is stirred for 5 min before steroid addition.

Sources & evidence

ORD record
ord-81ffc4330cd74284baa2b787081103d0
Source dataset
uspto-grants-1986_01
Patent number
US04567000

Reaction notes

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